Chair of Biochemistry and Molecular Biology

    Publications

    2017

    Dejure, F.R., Royla, N., Herold, S., Kalb, J., Walz, S., Ade, C.P., Mastrobuoni, G., Vanselow, J., Schlosser, A., Wolf, E., Kempa, S., and Eilers, M. (2017) The 3’-UTR of MYC couples RNA polymerase II function to ribonucleotide levels. EMBO J, Apr 13 doi:10.15252/embj.201796662. [Epub ahead of print]

    2016

    Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E, Different promoter affinities account for specificity in MYC-dependent gene regulation, eLife, 2016, e15161

    Vo BT*, Wolf E*, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M*, Roussel MF*, The interaction of Myc with Miz1 defines medulloblastoma subgroup identity, Cancer Cell, 2016, 29, 5-16 *joined first and senior authors

    Jung L A, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M, OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors, Oncogene, 2016

    King B, Boccalatte F, Moran-Crusio K, Wolf E, Wang J, Kayembe C, Lazaris C, Yu X, Aranda-Orgilles B, Lasorella A, Aifantis I, The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells, Nature Immunology, 2016; 17

    Jaenicke LA, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg A, Geyer M, Eilers M, and Popov N (2016). Ubiquitin-dependent turnover of MYC antagonizes MYC/PAF1C complex accumulation to drive transcriptional elongation. Mol Cell, 2016 Jan 7;61(1):54-67. doi: 10.1016/j.molcel.2015.11.007. Epub 2015 Dec 10.

    2015

    Küspert M, Murakawa Y, Schäffler K, Vanselow JT, Wolf E, Juranek S, Schlosser A, Landthaler M, Fischer U, LARP4B i an AU-rich sequence associated factor that promotes mRNA accumulation and translagtion, RNA, 2015

    Herter EK, Stauch M, Gallant M, Wolf E, Raabe T, Gallant P,snoRNAs are a novel class of biologically relevant Myc targets, BMC Biology, 2015, 13

    Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treismann R, Klefström J, Eilers M: Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells, EMBO J, 2015

    Wolf E, Lin CY, Eilers E, Levens DL, Taming of the beast: Shaping Myc-dependent amplification, Trends in Cell Biology, 2015, 25

    Weber D, Heisig J, Kneitz S, Wolf E, Eilers M, Gessler M: Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes, Journal of Molecular and Cellular Cardiology, 2015, 79, 79-88

    Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R. EMBO reports. 2015; 16(12):1723-36.

     

    2014

    Schülein-Völk C, Wolf E, Zhu J, Xu W, Taranets L, Hellmann A, Diefenbacher M, Behrens A, Eilers M, Popov N: Dual regulation of Fbw7 function and oncogenic transformation by Usp28, Cell Reports, 2014, 9, 1099-1109

    Muthalagu N, Junttila MR, Wiese KE, Wolf E, Morton J, Bauer B, Evan GI, Eilers M, Murphy DJ: BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues, Cell Reports, 2014, 8, 1347-1353

    Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wuestefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E*, Eilers M*: Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles, Nature, 2014, 511, 483-487 *these authors contributed equally , shared senior-authorship

    Baumgart S, Chen NM, Siveke JT, Koenig A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson DA, Urrutia R, Ellenrieder V: Inflammation induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer initiation by KrasG12D, Cancer Discovery, 2014, 4,  688-701

    Sanz-Moreno A, Fuhrmann D, Wolf E, von Eyss B, Eilers M, Elsässer HP: Miz1 deficiency in the mammary gland causes a lactation defect by attenuated stat5 expression and phosphorylation, PLos One, 2014, 9, e89187

    2013

    Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M: The role of MIZ-1 in MYC-dependent tumorigenesis, Cold Spring Harb Perspect Med, 2013, 3, a014290

    Wolf E*, Gebhardt A*, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M: Miz1 is required to maintain autophagic flux, Nature Communications, 2013, ncomms3535, *these authors contributed equally

    Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M: Target Gene Analysis by Microarrays and Chromatin Immunoprecipitation Identifies HEY Proteins as Highly Redundant bHLH Repressors, PLoS Genetics, 2012, 8, e1002728

    2012

    Wolf E, Kastner B, Lührmann R: Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex, RNA, 2012, 18, 1347-1357

    Hönnemann J, Sanz-Moreno A, Wolf E, Eilers M, Elsässer HP: Miz1 Is a Critical Repressor of cdkn1a during Skin Tumorigenesis, PLoS One, 2012, 7, e34885

    2011

    Agafonov DE, Deckert J, Wolf E, Odenwälder P, Bessonov S, Will CL, Urlaub H, Lührmann R: Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method, Molecular and cellular biology, 2011, 31, 2667-2682

    2010

    Golas MM, Sander B, Bessonov S, Grote M, Wolf E, Kastner B, Stark H, Lührmann R: 3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core, Molecular Cell, 2010, 40, 927-938

    Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A, Fischle W, Urlaub H, Lührmann R: Molecular architecture of the human Prp19/CDC5L complex, Molecular and cellular biology, 2010, 30, 2105-2119

    2009

    Wolf E, Kastner B, Deckert J, Merz C, Stark H, Lührmann R: Exon, intron and splice site locations in the spliceosomal B complex, EMBO J, 2009, 28, 2283-2292

    Herold N, Will CL, Wolf E, Kastner B, Urlaub H, Lührmann L: Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes, Molecular and cellular biology, 2009, 29, 281-301

    2008

    Häcker I, Sander B, Golas MM, Wolf E, Karagöz E, Kastner B, Stark H, Fabrizio P, Lührmann R: Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy, Nature structural and molecular biology, 2008, 15, 1206-1212

    Kastner B, Fischer N, Golas MM, Sander B, Dube P, Boehringer D, Hartmuth K, Deckert J, Hauer F, Wolf E, Uchtenhagen H, Urlaub H, Pörschke D, Lührmann R, Stark H: GraFix: Sample preparation for singleparticle electron cryomicroscopy, Nature Methods, 2008, 5, 53-55

    2005

    Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T: Single particle reconstructions of the Transferrin–Transferrin receptor complex obtained with different specimen preparation techniques, Journal of Molecular Biology, 2005, 355, 1048-1065

    Kontakt
    Lehrstuhl für Biochemie und Molekularbiologie
    Biozentrum
    Am Hubland
    97074 Würzburg

    Tel: +49 931 31-84112
    Fax: +49 931 31-84113

    Suche Ansprechpartner
    Hubland Süd Hubland Nord Campus Dallenberg Fabrikschleichach Humangenetik Campus Medizin