Deutsch
    Chair of Biochemistry and Molecular Biology

    Publications

    2017

    Dejure, F.R., Royla, N., Herold, S., Kalb, J., Walz, S., Ade, C.P., Mastrobuoni, G., Vanselow, J., Schlosser, A., Wolf, E., Kempa, S., and Eilers, M. (2017) The 3’-UTR of MYC couples RNA polymerase II function to ribonucleotide levels. EMBO J, Apr 13 doi:10.15252/embj.201796662. [Epub ahead of print]

    Sander, B., Xu, W., Eilers, M., Popov, N., and Lorenz, S. (2017) A conformational switch regulates the ubiquitin ligase HUWE1. Elife. 2017 Feb 14;6. pii: e21036. doi: 10.7554/eLife.21036.

    2016

    Jung, L.A., Gebhardt, A., Koelmel, W., Ade, C.P., Walz, S., Kuper, J., von Eyss, B., Letschert, S., Redel, C., d’Artista, L., Blankin, A., Zender, L., Sauer, M., Wolf, E., Evan, G., Kisker, C., and Eilers, M. (2016) OmoMyc blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene, Oct 17. doi:10.1038/onc.2016.354. Epub ahead of print.

    Richards, M.W., Burgess, S.G., Poon, E., Carstensen, A., Eilers, M., Chesler, L., and Bayliss, R. (2016) Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. PNAS, Nov 29;113(48):13726-13731. Epub Nov 11.

    Dardenne, E., Beltran, H., Benelli, M.,Gayvert, K., Berger, A., Puca, L., Cyrta, J., Sboner, A., Noorzad, Z., MacDonald, R., Cheung, C., Yuen, K.S., Gao, D., Chen, Y., Eilers, M., Mosquera, J.M., Robinson, B.D., Elemento, O., Rubin, M.A., Demichelis, F., and Rickman, D.S., (2016) N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer. Cancer Cell, Oct 10;30(4):563-577. doi: 10.1016/j.ccell.2016.09.005.

    Elster, D., Jaenicke, L.A., Eilers, M., and von Eyss, B. (2016) TEAD activity is restrained by MYC and stratifies human breast cancer subtypes. Cell Cycle, 15(19):2551-2556. Epub Jul 19.

    Lorenzin, F., Benary, U., Baluapuri, A., Walz, A., Jung, L.A., v. Eyß, B., Kisker, C., Wolf, J., Eilers, M., and Wolf, E., (2016) Different promoter affinities account for specificity in MYC-dependent gene regulation. eLife, e15161

    Dauch, D., Rudalska, R., Cossa, G., Nault, J.G., Kang, T.W., Wuestefeld, T., Hohmeyer, A., Imbeaud, S., Yevsa, T., Hoenicke, L., Pantsar, T., Bozko, P., Malek, N.P., Longerich, T., Laufer, S., Poso, A., Zucman-Rossi, J., Eilers, M., and Zender, L. (2016) A MYC-Aurka protein complex represents an actionable target in p53 altered liver cancer. Nature Medicine, 22(7):744-53. doi: 10.1038/nm.4107.

    Casey, S.C., Tong, L., Li, Y., Do, R., Walz, S., Fitzgerald, K.N., Gouw, A.M., Baylot, V., Guetgemann, I., Eilers, M., and Felsher, D.W. (2016) MYC Regulates the Anti-Tumor Immune Response through CD47 and PD-L1. Science, 52(6282):227-31. doi: 10.1126/science.aac9935

    Bonilla, X., Parmentier, L., King, B., Bezrukov, F., Kaya, G., Zoete, V., Seplyarskiy, V.B., Sharpe, H.J., McKee, T., Letourneau, A., Ribaux, P.G., Popadin, K., Basset-Seguin, N., Chaabene, R.B., Santoni, F.A., Andrianova, M.A., Guipponi, M., Garieri, M., Verdan, C., Grosdemange, K., Sumara, O., Eilers, M., Aifantis, I., Michielin, O., de Sauvage, F.J., Antonarakis, S.E., and Nikolaev, S.I. (2016) Genomic analysis reveals novel drivers and progression pathways in skin basal cell carcinoma. Nature Genetics, 48(4):398-406. doi: 10.1038/ng.3525.

    Haikala, H.M., Klefström, J., Eilers, M., and Wiese, K.W. (2016) Repression of lineage-specific gene signatures contributes to MYC-induced apoptosis in mammary epithelial cells. Cell Cycle. (3):316-23. doi: 10.1080/15384101.2015.1121351.

    Vo, B.T., Wolf, E., Kawauchi, D., Gebhardt, A., Rehg, J.E., Finkelstein, D., Walz, S., Murphy, B.L., Youn, Y.H., Han, Y.G., Eilers, M., and Roussel, M.F. (2016) The interaction of Myc with Miz1 defines medulloblastoma subgroup identity. Cancer Cell, 29:5-16.

    Jaenicke, L.A., von Eyss, B., Carstensen, A., Wolf, E., Xu, W., Greifenberg, A., Geyer, M., Eilers, M., and Popov, N. (2016). Ubiquitin-dependent turnover of MYC antagonizes MYC/PAF1C complex accumulation to drive transcriptional elongation. Mol Cell. 2016 Jan 7;61(1):54-67. doi: 10.1016/j.molcel.2015.11.007. Epub 2015 Dec 10.

    2015

    von Eyss, B., Jaenicke, L.A., Kortlever, R.M., Royla, N., Wiese, K.E., Letschert, L., McDuffus, L.A., Sauer, M., Rosenwald, A., Evan, G.I., Kempa, S., and Eilers, M. (2015) A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancer. Cancer Cell, 28:743-57.

    Elkon, R., Puch, F., Korkomaz, G., Lopes, R., van Breugel, P., Bleijerveld, O., Wolf, E., Altelaar. M., Eilers, M., and Agami, R. (2015) MYC coordinates extensive gene transcription and protein translation responses. EMBO Reports pii: e201540717.

    Buyandelger, B., Mansfield, C., Kostin, S., Choi, O., Roberts, A.M., Ware, J.S., Mazzarotto, F., Pesce, F., Buchan, R., Isaacson, R.L., Vouffo, J., Gunkel, S., Knöll, G., McSweeney, S.J., Wei, H., Perrot, A., Pfeiffer, C., Toliat, M.R., Ilieva, K., Krysztofinska, E., López-Olañeta, M.M., Gómez-Salinero, J.M., Schmidt, A., Ng, K.E., Teucher, N., Chen, J., Teichmann, M., Eilers, M., Haverkamp, W., Regitz-Zagrosek, V., Hasenfuss, G., Braun, T., Pennell, D.J., Gould, I., Barton, P.J., Lara-Pezzi, E., Schafer, S., Hübner, N., Felkin, L.E., O'Regan, D.P., Petretto, E., Brand, T., Milting, H., Nürnberg, P., Schneider, M.D., Prasad, S., and Knöll, R. (2015) ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Circ Cardiovasc Genet. pii: CIRCGENETICS.113.000690

    Wiegering, A., Uthe, F.W., Jamieson, T., Ruoss, Y., Hüttenrauch, M., Küspert, M., Pfann, C., Nixon C., Herold, S., Walz, S., Taranets, L., Germer, C.T., Rosenwald, A., Sansom, O.J., and Eilers, M. (2015) Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer. Cancer Discovery, 5:768-81.

    Wiese, K.E., Haikala, H.M., von Eyss, B., Wolf, E., Esnault, C., Rosenwald, A., Treisman, R., Klefstrom, J., and Eilers, M. (2015) Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. EMBO J. 34:1554-71.

    Diefenbacher, M.E., Atanu Chakraborty, Blake, S.M., Mitte, R., Popov, N., Eilers, M., and Behrens, A. (2015) Usp28 counteracts Fbw7 in intestinal homeostasis and cancer. Cancer Research 75:1181-6.

    Weber, D., Heisig, J., Kneitz, S., Wolf, E., Eilers, M., and Gessler, M. (2015) Mechanisms of epigenetic and celltype specific regulation of Hey target genes in ES cells and cardiomyocytes. Journal of Molecular and Cellular Cardiology 79:79-88.

    2014

    Schülein-Völk, C., Wolf, E., Zhu, J., Xu, W., Taranets, L., Hellmann, A., Jänicke, L.A., Diefenbacher, M.E., Behrens, A., Eilers, M., and Popov, N. (2014) Dual regulation of Fbw7 function and oncogenic transformation by Usp28. Cell Reports 9:1099-109.

    Gustafson, W.C., Meyerowitz, J.G., Nekritz, E.A., Chen, J., Benes, C., Charron, E., Simonds, E.F., Seeger, R., Matthay, K.K., Hertz, N.T., Eilers, M., Shokat, K.M. and Weiss, W.A. (2014) Drugging MYCN through an Allosteric Transition in Aurora Kinase A. Cancer Cell 26:414-27.

    Peter, S., Bultinck, J., Myant, K., Jaenicke, L.A., Walz, S., Müller, J., Gmachl, M., Treu, M., Boehmelt, G., Ade, C.P., Schmitz, W., Wiegering, A., Otto, C., Popov, N., Sansom, O., Kraut, N., and Eilers, M. (2014) Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. EMBO Molecular Medicine 6:1525-41.

    Muthalagu, N., Junttila, M., Wiese, K.E., Bauer, G., Eilers, M., Evan, G.I., and Murphy, D.J. (2014) Bim is a critical mediator of Myc-induced apoptosis in multiple solid tissues. Cell Reports 8:1347-53.

    Rudalska, R., Dauch, D., Longerich, T., McJunkin, K., Wuestefeld, T., Kang, T.W., Hohmeyer, A., Pesic, M., Leibold, J.,von Thun, A., Schirmacher, P., Zuber, J., Weiss, K.-H., Powers, S., Malek, N.-P., Eilers, M., Sipos, B., Lowe, S.W., Geffers, R.,Laufer, S., and Zender, L. (2014) In vivo RNAi screening identifies mechanisms of Sorafenib resistance in liver cancer. Nature Medicine 20:1138-46.

    Walz, S., Lorenzin, F., Morton, J., Wiese, K.E., von Eyss, B., Herold, S., Rycak, L., Dumay-Odelot, H., Karim, S., Bartkuhn, M., Roels, F., Wuestefeld, T., Fischer, M., Teichmann, M., Zender, L., Wei, C. L., Sansom, O., Wolf, E., and Eilers, M. (2014) Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles. Nature 511: 483-487.

    Diefenbacher, M.E., Popov, N., Blake, S.M., Schülein-Völk, C., Nye, E., Spencer-Dene, B., Jaenicke, L.A., Eilers, M., and Behrens A. (2014) The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. J. Clin Invest. 124:3407-18.

    Baumgart, S., Chen, N.M., Siveke, J.T., Koenig, A., Zhang, J.S., Singh, S.K., Wolf, E., Bartkuhn, M., Esposito, I., Heßmann, E., Reinecke, J., Nikorowitsch, J., Brunner, M., Singh, G., Fernandez-Zapico, M.E., Smyrk, T., Bamlet, W.R., Eilers, M., Neesse, A., Gress, T.M., Billadeau, D.D., Tuveson, D.A., Urrutia, R., and Ellenrieder, V. (2014) Inflammation induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D. Cancer Discovery 4:688-701.

    Sanz-Moreno, A., Fuhrmann, D., Wolf, E., von Eyss, B., Eilers, M., and Elsasser, H.P. (2014) Miz1 deficiency in the mammary gland causes a lactation defect by attenuated stat5 expression and phosphorylation. PLoS One 9: e89187.

    2013

    Wiegering, A., Pfann, C., Uthe, F.W., Otto, C., Rycak, L., Mäder, U., Gasser, M., Waaga-Gasser, A.M., Eilers M., and Germer, C.T. (2013) CIP2A influences survival in colon cancer and is critical for maintaining Myc expression. PLoS One 8:e75292.

    Wolf, E., Gebhardt, A., Kawauchi, D., Walz, S., Björn von Eyss, B., Wagner, N., Renninger, C., Krohne, G., Asan, E., Roussel, M., and Eilers, M. (2013) Miz1 is required to maintain autophagic flux. Nature Communications 4:2535.

    Brockmann, M., Poon, E., Berry, T., Carstensen, A., Deubzer, H.E., Rycak, L., Jamin, Y., Thway, K., Robinson, S.P., Roels, F., Witt, O. Fischer, M., Chesler, L., and Eilers, M. (2013) Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma. Cancer Cell 24: 75-89.

    Do-Umehara, H.C., Chen, C., Urich, D., Zhou, L., Qiu, J., Jang, S., Zander, A., Baker, M.A., Eilers, M., Sporn, P.H., Ridge, K.M., Sznajder, J.I., Budinger, G.R., Mutlu, G.M., Lin, A., and Liu, J. (2013) Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ. Nature Immunol. 14:461-469.

    Leikam, C., Hufnagel, A., Walz, S., Kneiitz, S., Fekete A., Müller M.J., Eilers, M., Schartl, M., and Meierjohann, S. (2013) Cystathionase mediates senescence evasion in melanocytes and melanoma cells. Oncogene 33:771-82.

    Leich, E., Weißbach, S., Klein, H.U., Grieb, T., Pischimarov, J., Stühmer, T., Chatterjee, M., Steinbrunn, T., Langer, C., Eilers, M., Knop, S., Einsele, H., Bargou, R., and Rosenwald, A. (2013) Multiple myeloma is affected by multiple and heterogeneous mutations in adhesion- and receptor tyrosine kinase signaling molecules. Blood Cancer J. 3:e102.

    2012

    Heisig, J., Weber, D., Englberger, E., Kneitz, S., Sung, W.-K., Wolf, E., Eilers, M., Wei, C.-L., and Gessler, M. (2012) Target gene analysis and chromatin immunoprecipitation identifies Hey proteins as highly redundant bHLH repressors. PLoS Genetics 8:e1002728.

    Hönnemann, J., Sanz-Moreno, A., Wolf, E., Eilers, M., and Elsässer, H. P. (2012) Miz1 is a critical repressor of cdkn1a during skin tumorigenesis. PLoS One 7:e34885.

    Liu, L., Ulbrich, J., Müller, J., Wüstefeld, T., Aeberhard, L., Kress, T.R., Muthalagu, N., Rudalska, R., Moll, R., Kempa, S., Zender, L., Eilers, M.*, and Murphy, D.J.* (2012) Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature 483:608-12* corresponding authors

    Morandell, D., Kaiser, A., Herold, S., Rostek, U., Lechner, S., Mitterberger1,M., Jansen-Dürr,  P., Eilers, M., and Zwerschke, W. (2012) The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1. Virology 422:242-53.

    2011

    Schülein, C., Eilers, M., and Popov, N. (2011) PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity. FEBS Lett. 585:2151-7.

    Kress, T.R., Cannell, I.G., Brenkman, A.B., Gaestel, M., N`Burgering, B.M., Bushell, M., Rosenwald, A., and Eilers, M. (2011) The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis. Molecular Cell 41:445-57.

    Iraci, N., Diolaiti, D., Papa, A., Porro, A., Valli, E., Gherardi, S., Herold, S., Eilers, M., Bernardoni, R., Della Valle, G., and Perini, G. (2011) A Sp1/Miz1/MycN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF. Cancer Res. 71:404-12.

    2010

    Kosan, C., Saba, I., Godmann, M., Herold, S., Herkert, B., Eilers, M., and Möröy, T. (2010) The BTB/POZ domain protein Miz-1 (Zbtb17) is required to regulate IL-7 receptor signaling at early commitment stages of B cell differentiation. Immunity 33:917-28.

    Müller, J., Samans, B., van Riggelen, J., Fagà, G., Peh, R., Wei, C.-L., Müller, H., Amati, B., Felsher, D., and Eilers, M. (2010) TGF beta-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas. Cell Cycle 9: 4622-4626.

    Popov, N., Schülein, C., Jaenicke, L., and Eilers, M. (2010) Ubiquitination of the Myc amino-terminus by beta-TrCP antagonizes Fbw7-mediated degradation. Nature Cell Biology 12:973-81.

    Teutschbein, J., Haydn, J.M., Samans, B., Krause, M., Eilers, M., Schartl, M., and Meierjohann S. (2010) Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins. BMC Cancer 10:386.

    Singh, G., Singh, S.K., Konig,A., Reutlinger, K., Nye, M.D., Adhikary, T., Eilers, M., Gress, T.M., Fernandez-Zapico, M.E., and Ellenrieder, V. (2010) Sequential activation of NFAT and c-MYC transcription factors mediates the TGF{beta} switch from a suppressor to a promoter of cancer cell proliferation. J. Biol. Chemistry 285: 27241-50.

    van Riggelen, J., Müller, J., Otto, T., Beuger, V., Samans, B., Yetil, A., Tao, J., Choi, P., Kosan, C., Möröy, T., Felsher, D., and Eilers, M. (2010) The interaction between Myc and Miz1 is required to suppress TGF beta-dependent senescence for initiation and maintenance of lymphomagenesis. Genes and Development 24:1281-1294.

    Beinoraviciute-Kellner, R., Schlereth, K., Sauer, M., Bretz, A.C., Beck, J., Leich, E., Samans, B., Eilers, M., Kisker, C., Rosenwald, A., and Stiewe, T. (2010) DNA binding cooperativity of p53 is essential for apoptosis but not cell cycle arrest. Molecular Cell 14:356-68.

    Cannell, I., Kong, Y., Johnston, S., Chen,M., Dobbyn, H.,Collins, H., Elia, A., Kress, T., Dickens, M., Clemens, M., Heery, D., Eilers, M., Willis, A., and Bushell, M. (2010) p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. PNAS 107: 5375-80.

    Herkert, B., Dwertmann, A., Herold, S., Naud, J.F., Finkernagel, F., Harms, G.S., Wanzel, M., and Eilers, M. (2010) The Arf tumor suppressor protein antagonizes Miz1 function to suppress cell adhesion and induce apoptosis. Journal of Cell Biology 188:905-18.

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